Drug interactions
Levofloxacin + Romidepsin
Severity: Moderate
Levofloxacin and Romidepsin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Romidepsin has been associated with ECG changes including QT prolongation, and levofloxacin also prolongs QT. Together they may raise the risk of serious ventricular arrhythmia, especially with hypokalemia or hypomagnesemia, which are common during romidepsin therapy.
What this interaction means in plain words
Levofloxacin and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Correct potassium and magnesium before each romidepsin dose and monitor ECG during coadministration. Consider a non-QT-prolonging antibiotic if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Levofloxacin with Romidepsin?
MediHelp rates the interaction as moderate. Levofloxacin and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Romidepsin has been associated with ECG changes including QT prolongation, and levofloxacin also prolongs QT. Together they may raise the risk of serious ventricular arrhythmia, especially with hypokalemia or hypomagnesemia, which are common during romidepsin therapy.
How serious is the interaction between Levofloxacin and Romidepsin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium before each romidepsin dose and monitor ECG during coadministration. Consider a non-QT-prolonging antibiotic if feasible.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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