Drug interactions
Levofloxacin + Sodium sulfate / ?magnesium sulfate / potassium chloride
Severity: Moderate
Levofloxacin and Sodium sulfate / ?magnesium sulfate / potassium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium in oral bowel preparations binds levofloxacin in the gut and reduces its absorption. This may lead to subtherapeutic antibiotic concentrations and treatment failure.
What this interaction means in plain words
Levofloxacin and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chelation of levofloxacin by magnesium cations in the gastrointestinal tract, reducing absorption.
What to do
Give oral levofloxacin at least 2 hours before or 2 hours after the preparation, or longer if the product labeling specifies. Consider timing the dose around the bowel preparation schedule.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Levofloxacin with Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates the interaction as moderate. Levofloxacin and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Magnesium in oral bowel preparations binds levofloxacin in the gut and reduces its absorption. This may lead to subtherapeutic antibiotic concentrations and treatment failure.
How serious is the interaction between Levofloxacin and Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oral levofloxacin at least 2 hours before or 2 hours after the preparation, or longer if the product labeling specifies. Consider timing the dose around the bowel preparation schedule.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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