Drug interactions
Levonorgestrel + Metformin-pioglitazone
Severity: Minor
Levonorgestrel and Metformin-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progestins such as levonorgestrel can slightly reduce glucose tolerance, but with low-dose or emergency use the effect on diabetes control is small. Clinically significant loss of glycemic control is uncommon.
What this interaction means in plain words
Levonorgestrel and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levonorgestrel belongs to Endocrine; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Progestins may modestly increase insulin resistance, opposing antidiabetic action.
What to do
No routine change is needed; check blood glucose a little more often when starting a hormonal contraceptive.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Other interactions of Levonorgestrel
Frequently asked questions
Can I take Levonorgestrel with Metformin-pioglitazone?
MediHelp rates the interaction as minor. Levonorgestrel and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Progestins such as levonorgestrel can slightly reduce glucose tolerance, but with low-dose or emergency use the effect on diabetes control is small. Clinically significant loss of glycemic control is uncommon.
How serious is the interaction between Levonorgestrel and Metformin-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; check blood glucose a little more often when starting a hormonal contraceptive.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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