Drug interactions
Levonorgestrel + Pitolisant
Severity: Moderate
Levonorgestrel and Pitolisant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pitolisant is a weak CYP3A4 inducer and may modestly lower levonorgestrel exposure. Pitolisant labeling advises that hormonal contraceptives may be less effective, so reliability could be reduced.
What this interaction means in plain words
Levonorgestrel and Pitolisant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levonorgestrel belongs to Endocrine; Pitolisant belongs to Central Nervous System.
Why it happens
Weak induction of CYP3A4 by pitolisant increases levonorgestrel metabolism.
What to do
Advise an additional non-hormonal contraceptive method during pitolisant treatment and for at least 21 days after stopping.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levonorgestrel
Other interactions of Pitolisant
- Alfuzosin + Pitolisant Major
- Amiodarone + Pitolisant Major
- Amisulpride + Pitolisant Major
- Anagrelide + Pitolisant Major
- Asenapine + Pitolisant Major
- Bupropion + Pitolisant Major
Frequently asked questions
Can I take Levonorgestrel with Pitolisant?
MediHelp rates the interaction as moderate. Levonorgestrel and Pitolisant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pitolisant is a weak CYP3A4 inducer and may modestly lower levonorgestrel exposure. Pitolisant labeling advises that hormonal contraceptives may be less effective, so reliability could be reduced.
How serious is the interaction between Levonorgestrel and Pitolisant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional non-hormonal contraceptive method during pitolisant treatment and for at least 21 days after stopping.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
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