Drug interactions
Levonorgestrel intrauterine + Secobarbital
Severity: Minor
Levonorgestrel intrauterine and Secobarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzyme-inducing barbiturates can reduce systemic levonorgestrel levels. With an intrauterine system the contraceptive effect is mainly local, so the clinical impact is probably small.
What this interaction means in plain words
Levonorgestrel intrauterine and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Induction of CYP3A4 increases levonorgestrel metabolism, though local intrauterine drug delivery limits the effect.
What to do
No change is usually needed for contraception with the intrauterine system. If the levonorgestrel is also given for endometrial protection alongside systemic estrogen, monitor for breakthrough bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Levonorgestrel intrauterine with Secobarbital?
MediHelp rates the interaction as minor. Levonorgestrel intrauterine and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Enzyme-inducing barbiturates can reduce systemic levonorgestrel levels. With an intrauterine system the contraceptive effect is mainly local, so the clinical impact is probably small.
How serious is the interaction between Levonorgestrel intrauterine and Secobarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change is usually needed for contraception with the intrauterine system. If the levonorgestrel is also given for endometrial protection alongside systemic estrogen, monitor for breakthrough bleeding.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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