Drug interactions
Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate + Neomycin
Severity: Minor
Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate and Neomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin may theoretically reduce enterohepatic recycling of ethinylestradiol by altering intestinal flora. Controlled data show little effect on contraceptive efficacy for non-enzyme-inducing antibiotics, although rare failures have been reported.
What this interaction means in plain words
Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate and Neomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible reduction of ethinylestradiol enterohepatic recirculation via altered gut flora, not firmly established.
What to do
No routine change is needed for short courses. Advise reporting of vomiting or diarrhea and consider backup barrier contraception if therapy is prolonged.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Neomycin
- Amikacin + Neomycin Major
- Amphotericin b deoxycholate + Neomycin Major
- Capreomycin + Neomycin Major
- Cidofovir + Neomycin Major
- Colistin + Neomycin Major
- Ethacrynic acid + Neomycin Major
Frequently asked questions
Can I take Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate with Neomycin?
MediHelp rates the interaction as minor. Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate and Neomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral neomycin may theoretically reduce enterohepatic recycling of ethinylestradiol by altering intestinal flora. Controlled data show little effect on contraceptive efficacy for non-enzyme-inducing antibiotics, although rare failures have been reported.
How serious is the interaction between Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate and Neomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed for short courses. Advise reporting of vomiting or diarrhea and consider backup barrier contraception if therapy is prolonged.
What other medicines interact with Neomycin?
MediHelp also lists interactions of Neomycin with, for example, Amikacin, Amphotericin b deoxycholate, Capreomycin. The full list is on the Neomycin page.
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