Drug interactions
Levorphanol + Methocarbamol
Severity: Major
Levorphanol and Methocarbamol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levorphanol is a potent opioid analgesic. With sedating methocarbamol, the risk of profound sedation, respiratory depression and impaired psychomotor function is increased.
What this interaction means in plain words
Levorphanol and Methocarbamol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from opioid agonism and methocarbamol's central depressant effect.
What to do
Use the lowest effective doses and titrate slowly. Monitor sedation and respiratory rate, and avoid in patients with compromised breathing.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Methocarbamol
Frequently asked questions
Can I take Levorphanol with Methocarbamol?
MediHelp rates the interaction as major. Levorphanol and Methocarbamol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Levorphanol is a potent opioid analgesic. With sedating methocarbamol, the risk of profound sedation, respiratory depression and impaired psychomotor function is increased.
How serious is the interaction between Levorphanol and Methocarbamol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and titrate slowly. Monitor sedation and respiratory rate, and avoid in patients with compromised breathing.
What other medicines interact with Methocarbamol?
MediHelp also lists interactions of Methocarbamol with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Methocarbamol page.
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