Drug interactions
Levorphanol + Oxymorphone
Severity: Major
Levorphanol and Oxymorphone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are full mu-opioid agonists, so using them together adds to analgesia but also to sedation, respiratory depression and overdose risk. Duplicate opioid therapy is rarely justified and increases the chance of dosing errors.
What this interaction means in plain words
Levorphanol and Oxymorphone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive mu-opioid receptor agonism producing CNS and respiratory depression.
What to do
Avoid concurrent use of two scheduled opioids unless deliberately converting therapy. If overlap is needed, reduce doses and monitor for sedation and respiratory rate.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Levorphanol with Oxymorphone?
MediHelp rates the interaction as major. Levorphanol and Oxymorphone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are full mu-opioid agonists, so using them together adds to analgesia but also to sedation, respiratory depression and overdose risk. Duplicate opioid therapy is rarely justified and increases the chance of dosing errors.
How serious is the interaction between Levorphanol and Oxymorphone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two scheduled opioids unless deliberately converting therapy. If overlap is needed, reduce doses and monitor for sedation and respiratory rate.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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