Drug interactions
Levorphanol + Procarbazine
Severity: Major
Levorphanol and Procarbazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has MAO inhibiting activity, and MAOIs can cause unpredictable reactions with opioids, including serotonin syndrome, CNS and respiratory depression and hypotension.
What this interaction means in plain words
Levorphanol and Procarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
MAO inhibition may enhance serotonergic and CNS depressant effects of the opioid; exact mechanism for levorphanol is not well defined.
What to do
Avoid levorphanol during procarbazine therapy and for 14 days after stopping. If an opioid is essential, use minimal doses and monitor blood pressure, respiration and mental status.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Levorphanol with Procarbazine?
MediHelp rates the interaction as major. Levorphanol and Procarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Procarbazine has MAO inhibiting activity, and MAOIs can cause unpredictable reactions with opioids, including serotonin syndrome, CNS and respiratory depression and hypotension.
How serious is the interaction between Levorphanol and Procarbazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid levorphanol during procarbazine therapy and for 14 days after stopping. If an opioid is essential, use minimal doses and monitor blood pressure, respiration and mental status.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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