Drug interactions
Levorphanol + Ramelteon
Severity: Moderate
Levorphanol and Ramelteon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levorphanol is a potent opioid that causes sedation and respiratory depression. Ramelteon adds to drowsiness and psychomotor impairment, though ramelteon has little respiratory depressant effect.
What this interaction means in plain words
Levorphanol and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression.
What to do
Counsel on drowsiness and avoiding driving; monitor sedation and respiratory status, particularly at opioid initiation or dose increases.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Levorphanol with Ramelteon?
MediHelp rates the interaction as moderate. Levorphanol and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levorphanol is a potent opioid that causes sedation and respiratory depression. Ramelteon adds to drowsiness and psychomotor impairment, though ramelteon has little respiratory depressant effect.
How serious is the interaction between Levorphanol and Ramelteon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on drowsiness and avoiding driving; monitor sedation and respiratory status, particularly at opioid initiation or dose increases.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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