Drug interactions
Levosalbutamol + Maprotiline
Severity: Moderate
Levosalbutamol and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline, a tetracyclic antidepressant, can potentiate the cardiovascular effects of beta-agonists such as levosalbutamol, with tachycardia and arrhythmia. Patients with heart disease are most at risk.
What this interaction means in plain words
Levosalbutamol and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levosalbutamol belongs to Respiratory; Maprotiline belongs to Central Nervous System.
Why it happens
Maprotiline blocks norepinephrine reuptake and has additive adrenergic and QT-prolonging effects with beta-agonist-induced tachycardia and hypokalemia.
What to do
Monitor heart rate and rhythm, and obtain an ECG in patients with cardiac disease. Use the lowest effective levosalbutamol dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levosalbutamol
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Levosalbutamol with Maprotiline?
MediHelp rates the interaction as moderate. Levosalbutamol and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maprotiline, a tetracyclic antidepressant, can potentiate the cardiovascular effects of beta-agonists such as levosalbutamol, with tachycardia and arrhythmia. Patients with heart disease are most at risk.
How serious is the interaction between Levosalbutamol and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and rhythm, and obtain an ECG in patients with cardiac disease. Use the lowest effective levosalbutamol dose.
What other medicines interact with Levosalbutamol?
MediHelp also lists interactions of Levosalbutamol with, for example, Amisulpride, Carvedilol, Fexinidazole. The full list is on the Levosalbutamol page.
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