Drug interactions
Levosalbutamol + Nebivolol
Severity: Moderate
Levosalbutamol and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers oppose the bronchodilator action of levosalbutamol and may provoke bronchospasm in patients with asthma or COPD. Nebivolol is relatively beta-1 selective, so the effect is less pronounced at low doses, but selectivity is lost as the dose rises.
What this interaction means in plain words
Levosalbutamol and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levosalbutamol belongs to Respiratory; Nebivolol belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism at beta-adrenergic receptors, with loss of beta-1 selectivity at higher nebivolol doses.
What to do
Monitor respiratory status and bronchodilator response, and use the lowest effective nebivolol dose. If bronchospasm occurs, reassess the need for the beta-blocker, as it may blunt the rescue effect of levosalbutamol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Levosalbutamol and Nebivolol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Levosalbutamol
Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Levosalbutamol with Nebivolol?
MediHelp rates the interaction as moderate. Levosalbutamol and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers oppose the bronchodilator action of levosalbutamol and may provoke bronchospasm in patients with asthma or COPD. Nebivolol is relatively beta-1 selective, so the effect is less pronounced at low doses, but selectivity is lost as the dose rises.
How serious is the interaction between Levosalbutamol and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory status and bronchodilator response, and use the lowest effective nebivolol dose. If bronchospasm occurs, reassess the need for the beta-blocker, as it may blunt the rescue effect of levosalbutamol.
What other medicines interact with Levosalbutamol?
MediHelp also lists interactions of Levosalbutamol with, for example, Amisulpride, Carvedilol, Fexinidazole. The full list is on the Levosalbutamol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
