Drug interactions
Lidocaine + Timolol
Severity: Moderate
Lidocaine and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers reduce hepatic blood flow and lidocaine clearance, which can raise lidocaine levels and toxicity risk with systemic or infusion use. With epinephrine-containing local anesthetics, nonselective beta-blockade can cause unopposed alpha stimulation, with hypertension and reflex bradycardia.
What this interaction means in plain words
Lidocaine and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lidocaine belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Why it happens
Reduced hepatic blood flow lowers lidocaine clearance, and nonselective beta-blockade permits unopposed epinephrine alpha effects.
What to do
Monitor lidocaine levels and signs of toxicity during infusions and consider lowering the dose. Use epinephrine-containing anesthetics sparingly and monitor blood pressure and pulse.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Frequently asked questions
Can I take Lidocaine with Timolol?
MediHelp rates the interaction as moderate. Lidocaine and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers reduce hepatic blood flow and lidocaine clearance, which can raise lidocaine levels and toxicity risk with systemic or infusion use. With epinephrine-containing local anesthetics, nonselective beta-blockade can cause unopposed alpha stimulation, with hypertension and reflex bradycardia.
How serious is the interaction between Lidocaine and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lidocaine levels and signs of toxicity during infusions and consider lowering the dose. Use epinephrine-containing anesthetics sparingly and monitor blood pressure and pulse.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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