Drug interactions
Lidocaine-prilocaine + Midazolam intranasal
Severity: Minor
Lidocaine-prilocaine and Midazolam intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lidocaine is a weak CYP3A4 substrate and inhibitor, so any increase in midazolam exposure from topical lidocaine-prilocaine would be small. Prolonged sedation is theoretically possible but unlikely with topical use.
What this interaction means in plain words
Lidocaine-prilocaine and Midazolam intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak competitive CYP3A4 inhibition by lidocaine may slightly reduce midazolam clearance.
What to do
No dose adjustment is needed. Monitor sedation level as usual after midazolam.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lidocaine-prilocaine
- Lidocaine-prilocaine + Phenazopyridine Major
- Bupivacaine implant + Lidocaine-prilocaine Moderate
- Bupivacaine liposome + Lidocaine-prilocaine Moderate
- Disopyramide + Lidocaine-prilocaine Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lidocaine-prilocaine Moderate
- Lidocaine-prilocaine + Mexiletine Moderate
Frequently asked questions
Can I take Lidocaine-prilocaine with Midazolam intranasal?
MediHelp rates the interaction as minor. Lidocaine-prilocaine and Midazolam intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lidocaine is a weak CYP3A4 substrate and inhibitor, so any increase in midazolam exposure from topical lidocaine-prilocaine would be small. Prolonged sedation is theoretically possible but unlikely with topical use.
How serious is the interaction between Lidocaine-prilocaine and Midazolam intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor sedation level as usual after midazolam.
What other medicines interact with Lidocaine-prilocaine?
MediHelp also lists interactions of Lidocaine-prilocaine with, for example, Phenazopyridine, Bupivacaine implant, Bupivacaine liposome. The full list is on the Lidocaine-prilocaine page.
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