Drug interactions
Lidocaine-prilocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir
Severity: Moderate
Lidocaine-prilocaine and Ombitasvir / paritaprevir / ritonavir and dasabuvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-boosted regimens strongly inhibit CYP3A4 and can increase lidocaine concentrations, raising the risk of toxicity. With topical lidocaine-prilocaine the systemic exposure is low, but large or prolonged application could be relevant.
What this interaction means in plain words
Lidocaine-prilocaine and Ombitasvir / paritaprevir / ritonavir and dasabuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ritonavir and paritaprevir inhibit CYP3A4, reducing lidocaine metabolism.
What to do
Limit the application area and duration of the cream. Monitor for signs of lidocaine toxicity such as dizziness, tremor or arrhythmia if extensive use is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lidocaine-prilocaine
- Lidocaine-prilocaine + Phenazopyridine Major
- Bupivacaine implant + Lidocaine-prilocaine Moderate
- Bupivacaine liposome + Lidocaine-prilocaine Moderate
- Disopyramide + Lidocaine-prilocaine Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lidocaine-prilocaine Moderate
- Lidocaine-prilocaine + Mexiletine Moderate
Frequently asked questions
Can I take Lidocaine-prilocaine with Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates the interaction as moderate. Lidocaine-prilocaine and Ombitasvir / paritaprevir / ritonavir and dasabuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir-boosted regimens strongly inhibit CYP3A4 and can increase lidocaine concentrations, raising the risk of toxicity. With topical lidocaine-prilocaine the systemic exposure is low, but large or prolonged application could be relevant.
How serious is the interaction between Lidocaine-prilocaine and Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the application area and duration of the cream. Monitor for signs of lidocaine toxicity such as dizziness, tremor or arrhythmia if extensive use is needed.
What other medicines interact with Lidocaine-prilocaine?
MediHelp also lists interactions of Lidocaine-prilocaine with, for example, Phenazopyridine, Bupivacaine implant, Bupivacaine liposome. The full list is on the Lidocaine-prilocaine page.
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