Drug interactions
Lidocaine-prilocaine + Phenobarbital
Severity: Minor
Lidocaine-prilocaine and Phenobarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital induces hepatic enzymes including CYP3A4 and may lower lidocaine concentrations. With topical use the systemic effect is small and clinically minor.
What this interaction means in plain words
Lidocaine-prilocaine and Phenobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Phenobarbital induces hepatic metabolism of lidocaine.
What to do
No adjustment is needed for topical use. If systemic lidocaine is used for arrhythmia, monitor for reduced effect.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lidocaine-prilocaine
- Lidocaine-prilocaine + Phenazopyridine Major
- Bupivacaine implant + Lidocaine-prilocaine Moderate
- Bupivacaine liposome + Lidocaine-prilocaine Moderate
- Disopyramide + Lidocaine-prilocaine Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lidocaine-prilocaine Moderate
- Lidocaine-prilocaine + Mexiletine Moderate
Frequently asked questions
Can I take Lidocaine-prilocaine with Phenobarbital?
MediHelp rates the interaction as minor. Lidocaine-prilocaine and Phenobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenobarbital induces hepatic enzymes including CYP3A4 and may lower lidocaine concentrations. With topical use the systemic effect is small and clinically minor.
How serious is the interaction between Lidocaine-prilocaine and Phenobarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed for topical use. If systemic lidocaine is used for arrhythmia, monitor for reduced effect.
What other medicines interact with Lidocaine-prilocaine?
MediHelp also lists interactions of Lidocaine-prilocaine with, for example, Phenazopyridine, Bupivacaine implant, Bupivacaine liposome. The full list is on the Lidocaine-prilocaine page.
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