Drug interactions
Lidocaine-prilocaine + Pindolol
Severity: Minor
Lidocaine-prilocaine and Pindolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers can reduce hepatic blood flow and lidocaine clearance, and may add to cardiac depression such as bradycardia. With topical lidocaine-prilocaine the systemic exposure is low, so the effect is generally minor.
What this interaction means in plain words
Lidocaine-prilocaine and Pindolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Reduced hepatic blood flow lowers lidocaine clearance, with additive negative chronotropic and inotropic effects.
What to do
Use labeled topical doses and avoid large-area application. Monitor heart rate and blood pressure if substantial absorption is possible.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lidocaine-prilocaine
- Lidocaine-prilocaine + Phenazopyridine Major
- Bupivacaine implant + Lidocaine-prilocaine Moderate
- Bupivacaine liposome + Lidocaine-prilocaine Moderate
- Disopyramide + Lidocaine-prilocaine Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lidocaine-prilocaine Moderate
- Lidocaine-prilocaine + Mexiletine Moderate
Frequently asked questions
Can I take Lidocaine-prilocaine with Pindolol?
MediHelp rates the interaction as minor. Lidocaine-prilocaine and Pindolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Beta-blockers can reduce hepatic blood flow and lidocaine clearance, and may add to cardiac depression such as bradycardia. With topical lidocaine-prilocaine the systemic exposure is low, so the effect is generally minor.
How serious is the interaction between Lidocaine-prilocaine and Pindolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use labeled topical doses and avoid large-area application. Monitor heart rate and blood pressure if substantial absorption is possible.
What other medicines interact with Lidocaine-prilocaine?
MediHelp also lists interactions of Lidocaine-prilocaine with, for example, Phenazopyridine, Bupivacaine implant, Bupivacaine liposome. The full list is on the Lidocaine-prilocaine page.
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