Drug interactions
Lidocaine-prilocaine + Pipemidic acid
Severity: Minor
Lidocaine-prilocaine and Pipemidic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pipemidic acid inhibits CYP1A2 and may reduce lidocaine clearance. With topical lidocaine-prilocaine, systemic exposure is low and the effect is likely small.
What this interaction means in plain words
Lidocaine-prilocaine and Pipemidic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pipemidic acid inhibits CYP1A2-mediated lidocaine metabolism.
What to do
No routine change is needed. Limit area and duration of application and watch for signs of lidocaine toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lidocaine-prilocaine and Pipemidic acid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Lidocaine-prilocaine
- Lidocaine-prilocaine + Phenazopyridine Major
- Bupivacaine implant + Lidocaine-prilocaine Moderate
- Bupivacaine liposome + Lidocaine-prilocaine Moderate
- Disopyramide + Lidocaine-prilocaine Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lidocaine-prilocaine Moderate
- Lidocaine-prilocaine + Mexiletine Moderate
Frequently asked questions
Can I take Lidocaine-prilocaine with Pipemidic acid?
MediHelp rates the interaction as minor. Lidocaine-prilocaine and Pipemidic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pipemidic acid inhibits CYP1A2 and may reduce lidocaine clearance. With topical lidocaine-prilocaine, systemic exposure is low and the effect is likely small.
How serious is the interaction between Lidocaine-prilocaine and Pipemidic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Limit area and duration of application and watch for signs of lidocaine toxicity.
What other medicines interact with Lidocaine-prilocaine?
MediHelp also lists interactions of Lidocaine-prilocaine with, for example, Phenazopyridine, Bupivacaine implant, Bupivacaine liposome. The full list is on the Lidocaine-prilocaine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
