Drug interactions
Lidocaine-prilocaine + Ponatinib
Severity: Minor
Lidocaine-prilocaine and Ponatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponatinib inhibits P-glycoprotein and could modestly raise exposure to P-gp substrates. Lidocaine is a minor P-gp substrate and topical absorption is low, so the practical effect is expected to be negligible.
What this interaction means in plain words
Lidocaine-prilocaine and Ponatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lidocaine-prilocaine belongs to Genitourinary; Ponatinib belongs to Oncology.
Why it happens
P-glycoprotein inhibition by ponatinib may reduce lidocaine efflux.
What to do
No specific action is needed for standard topical use. Avoid excessive dosing.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lidocaine-prilocaine
- Lidocaine-prilocaine + Phenazopyridine Major
- Bupivacaine implant + Lidocaine-prilocaine Moderate
- Bupivacaine liposome + Lidocaine-prilocaine Moderate
- Disopyramide + Lidocaine-prilocaine Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lidocaine-prilocaine Moderate
- Lidocaine-prilocaine + Mexiletine Moderate
Other interactions of Ponatinib
Frequently asked questions
Can I take Lidocaine-prilocaine with Ponatinib?
MediHelp rates the interaction as minor. Lidocaine-prilocaine and Ponatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ponatinib inhibits P-glycoprotein and could modestly raise exposure to P-gp substrates. Lidocaine is a minor P-gp substrate and topical absorption is low, so the practical effect is expected to be negligible.
How serious is the interaction between Lidocaine-prilocaine and Ponatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed for standard topical use. Avoid excessive dosing.
What other medicines interact with Lidocaine-prilocaine?
MediHelp also lists interactions of Lidocaine-prilocaine with, for example, Phenazopyridine, Bupivacaine implant, Bupivacaine liposome. The full list is on the Lidocaine-prilocaine page.
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