Drug interactions
Lidocaine-prilocaine + Procainamide
Severity: Moderate
Lidocaine-prilocaine and Procainamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procainamide and lidocaine both slow cardiac conduction and can have additive effects, including conduction block or CNS toxicity if systemic lidocaine levels are significant. With topical lidocaine-prilocaine absorption is low, so the risk is modest but rises with large-area use or in patients with conduction disease.
What this interaction means in plain words
Lidocaine-prilocaine and Procainamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sodium channel blockade and depression of cardiac conduction.
What to do
Keep topical dosing within limits and monitor ECG in patients with conduction disorders or renal impairment. Avoid large-area or occluded application.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lidocaine-prilocaine
- Lidocaine-prilocaine + Phenazopyridine Major
- Bupivacaine implant + Lidocaine-prilocaine Moderate
- Bupivacaine liposome + Lidocaine-prilocaine Moderate
- Disopyramide + Lidocaine-prilocaine Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lidocaine-prilocaine Moderate
- Lidocaine-prilocaine + Mexiletine Moderate
Frequently asked questions
Can I take Lidocaine-prilocaine with Procainamide?
MediHelp rates the interaction as moderate. Lidocaine-prilocaine and Procainamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procainamide and lidocaine both slow cardiac conduction and can have additive effects, including conduction block or CNS toxicity if systemic lidocaine levels are significant. With topical lidocaine-prilocaine absorption is low, so the risk is modest but rises with large-area use or in patients with conduction disease.
How serious is the interaction between Lidocaine-prilocaine and Procainamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep topical dosing within limits and monitor ECG in patients with conduction disorders or renal impairment. Avoid large-area or occluded application.
What other medicines interact with Lidocaine-prilocaine?
MediHelp also lists interactions of Lidocaine-prilocaine with, for example, Phenazopyridine, Bupivacaine implant, Bupivacaine liposome. The full list is on the Lidocaine-prilocaine page.
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