Drug interactions
Lily of the valley + Quinidine
Severity: Major
Lily of the valley and Quinidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lily of the valley contains cardiac glycosides similar to digoxin, and quinidine can increase glycoside levels and also affect conduction. The combination may increase the risk of arrhythmia and glycoside toxicity.
What this interaction means in plain words
Lily of the valley and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive cardiac glycoside effects on conduction, with quinidine possibly reducing glycoside clearance via P-gp inhibition.
What to do
Avoid concurrent use of lily of the valley preparations with quinidine; if exposure occurs, obtain an ECG and check potassium and glycoside levels.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Lily of the valley with Quinidine?
MediHelp rates the interaction as major. Lily of the valley and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lily of the valley contains cardiac glycosides similar to digoxin, and quinidine can increase glycoside levels and also affect conduction. The combination may increase the risk of arrhythmia and glycoside toxicity.
How serious is the interaction between Lily of the valley and Quinidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of lily of the valley preparations with quinidine; if exposure occurs, obtain an ECG and check potassium and glycoside levels.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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