Drug interactions
Linagliptin-metformin + Ombitasvir / paritaprevir / ritonavir and dasabuvir
Severity: Moderate
Linagliptin-metformin and Ombitasvir / paritaprevir / ritonavir and dasabuvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-boosted regimens inhibit CYP3A4 and P-gp and may increase linagliptin exposure, usually without clinical consequence. Metformin exposure is not markedly changed, but the label cautions on lactic acidosis risk when renal or hepatic function is impaired. Glucose levels may also change as hepatitis C is treated.
What this interaction means in plain words
Linagliptin-metformin and Ombitasvir / paritaprevir / ritonavir and dasabuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ritonavir and paritaprevir inhibit CYP3A4, P-gp and transporters, mildly raising linagliptin and possibly metformin exposure.
What to do
Monitor renal function and watch for lactic acidosis symptoms, and check glucose regularly during treatment since requirements may fall as HCV is cleared.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Linagliptin-metformin and Ombitasvir / paritaprevir / ritonavir and dasabuvir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Linagliptin-metformin
Frequently asked questions
Can I take Linagliptin-metformin with Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates the interaction as moderate. Linagliptin-metformin and Ombitasvir / paritaprevir / ritonavir and dasabuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir-boosted regimens inhibit CYP3A4 and P-gp and may increase linagliptin exposure, usually without clinical consequence. Metformin exposure is not markedly changed, but the label cautions on lactic acidosis risk when renal or hepatic function is impaired. Glucose levels may also change as hepatitis C is treated.
How serious is the interaction between Linagliptin-metformin and Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and watch for lactic acidosis symptoms, and check glucose regularly during treatment since requirements may fall as HCV is cleared.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
