Drug interactions
Linagliptin-metformin + Perindopril
Severity: Moderate
Linagliptin-metformin and Perindopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may enhance insulin sensitivity and are occasionally associated with hypoglycemia in patients on antidiabetic drugs. They can also reduce renal function in susceptible patients, which may raise metformin exposure and lactic acidosis risk.
What this interaction means in plain words
Linagliptin-metformin and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linagliptin-metformin belongs to Endocrine; Perindopril belongs to Cardiovascular.
Why it happens
ACE inhibition may improve insulin sensitivity, and renal hemodynamic effects can reduce metformin clearance.
What to do
Monitor blood glucose and renal function after initiation or dose changes, and reassess metformin dosing if eGFR declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Frequently asked questions
Can I take Linagliptin-metformin with Perindopril?
MediHelp rates the interaction as moderate. Linagliptin-metformin and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors may enhance insulin sensitivity and are occasionally associated with hypoglycemia in patients on antidiabetic drugs. They can also reduce renal function in susceptible patients, which may raise metformin exposure and lactic acidosis risk.
How serious is the interaction between Linagliptin-metformin and Perindopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function after initiation or dose changes, and reassess metformin dosing if eGFR declines.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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