Drug interactions
Linagliptin-metformin + Phenobarbital
Severity: Moderate
Linagliptin-metformin and Phenobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital induces CYP3A4 and P-gp and may lower linagliptin concentrations, reducing efficacy. Labeling advises considering alternatives when linagliptin is used with strong inducers.
What this interaction means in plain words
Linagliptin-metformin and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 and P-gp induction increases linagliptin clearance.
What to do
Monitor glucose and HbA1c and consider switching to a non-CYP3A4-dependent agent if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Frequently asked questions
Can I take Linagliptin-metformin with Phenobarbital?
MediHelp rates the interaction as moderate. Linagliptin-metformin and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenobarbital induces CYP3A4 and P-gp and may lower linagliptin concentrations, reducing efficacy. Labeling advises considering alternatives when linagliptin is used with strong inducers.
How serious is the interaction between Linagliptin-metformin and Phenobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c and consider switching to a non-CYP3A4-dependent agent if control worsens.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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