Drug interactions
Linagliptin-metformin + Phenytoin
Severity: Moderate
Linagliptin-metformin and Phenytoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin induces CYP3A4 and P-glycoprotein, which may substantially reduce linagliptin exposure and efficacy. Phenytoin can also inhibit insulin release and raise blood glucose, further weakening glycemic control.
What this interaction means in plain words
Linagliptin-metformin and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linagliptin-metformin belongs to Endocrine; Phenytoin belongs to Central Nervous System.
Why it happens
Enzyme and transporter induction lowers linagliptin levels, and phenytoin impairs pancreatic insulin secretion.
What to do
Monitor glucose and HbA1c closely and consider an alternative to linagliptin if control is inadequate while on phenytoin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Frequently asked questions
Can I take Linagliptin-metformin with Phenytoin?
MediHelp rates the interaction as moderate. Linagliptin-metformin and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenytoin induces CYP3A4 and P-glycoprotein, which may substantially reduce linagliptin exposure and efficacy. Phenytoin can also inhibit insulin release and raise blood glucose, further weakening glycemic control.
How serious is the interaction between Linagliptin-metformin and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c closely and consider an alternative to linagliptin if control is inadequate while on phenytoin.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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