Drug interactions
Linagliptin-metformin + Quinapril
Severity: Moderate
Linagliptin-metformin and Quinapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can enhance insulin sensitivity and occasionally lead to hypoglycemia in patients on antidiabetic drugs. They may also reduce renal function in susceptible patients, which could raise metformin exposure and the risk of lactic acidosis.
What this interaction means in plain words
Linagliptin-metformin and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Improved insulin sensitivity from ACE inhibition (additive glucose lowering), plus possible renal function decline that reduces metformin clearance.
What to do
Monitor blood glucose and renal function (eGFR) after starting or adjusting quinapril, especially in the elderly or those with renal impairment. Reduce or stop metformin if renal function falls substantially.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Frequently asked questions
Can I take Linagliptin-metformin with Quinapril?
MediHelp rates the interaction as moderate. Linagliptin-metformin and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can enhance insulin sensitivity and occasionally lead to hypoglycemia in patients on antidiabetic drugs. They may also reduce renal function in susceptible patients, which could raise metformin exposure and the risk of lactic acidosis.
How serious is the interaction between Linagliptin-metformin and Quinapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function (eGFR) after starting or adjusting quinapril, especially in the elderly or those with renal impairment. Reduce or stop metformin if renal function falls substantially.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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