Drug interactions
Linagliptin-metformin + Sulfamethoxypyridazine
Severity: Minor
Linagliptin-metformin and Sulfamethoxypyridazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfonamide antibacterials have been associated with hypoglycemia, mainly with sulfonylureas. With metformin and linagliptin, which carry a low intrinsic hypoglycemia risk, a clinically important effect is uncommon.
What this interaction means in plain words
Linagliptin-metformin and Sulfamethoxypyridazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive glucose lowering; the mechanism is not well established for this combination.
What to do
Monitor blood glucose during sulfonamide therapy, particularly in patients with renal impairment or poor intake.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin-metformin
Frequently asked questions
Can I take Linagliptin-metformin with Sulfamethoxypyridazine?
MediHelp rates the interaction as minor. Linagliptin-metformin and Sulfamethoxypyridazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfonamide antibacterials have been associated with hypoglycemia, mainly with sulfonylureas. With metformin and linagliptin, which carry a low intrinsic hypoglycemia risk, a clinically important effect is uncommon.
How serious is the interaction between Linagliptin-metformin and Sulfamethoxypyridazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during sulfonamide therapy, particularly in patients with renal impairment or poor intake.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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