Drug interactions
Linagliptin-metformin + Tenofovir df
Severity: Moderate
Linagliptin-metformin and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir DF can cause renal tubular injury and reduce renal function, which may lead to metformin accumulation and lactic acidosis. Competition for renal transporters has also been proposed.
What this interaction means in plain words
Linagliptin-metformin and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Tenofovir-related nephrotoxicity and possible transporter competition reduce renal elimination of metformin.
What to do
Monitor renal function (eGFR) regularly and watch for signs of lactic acidosis. Reduce or stop metformin if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Frequently asked questions
Can I take Linagliptin-metformin with Tenofovir df?
MediHelp rates the interaction as moderate. Linagliptin-metformin and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir DF can cause renal tubular injury and reduce renal function, which may lead to metformin accumulation and lactic acidosis. Competition for renal transporters has also been proposed.
How serious is the interaction between Linagliptin-metformin and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function (eGFR) regularly and watch for signs of lactic acidosis. Reduce or stop metformin if renal function declines.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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