Drug interactions
Linagliptin-metformin + Trifluoperazine
Severity: Moderate
Linagliptin-metformin and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazine antipsychotics can impair glucose tolerance and may raise blood glucose, reducing the effect of antidiabetic drugs. Trifluoperazine has a lower metabolic liability than some other antipsychotics, so the effect is usually modest.
What this interaction means in plain words
Linagliptin-metformin and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antipsychotic-related impairment of insulin secretion and sensitivity opposes glucose lowering.
What to do
Monitor blood glucose when trifluoperazine is started or stopped and adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Frequently asked questions
Can I take Linagliptin-metformin with Trifluoperazine?
MediHelp rates the interaction as moderate. Linagliptin-metformin and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazine antipsychotics can impair glucose tolerance and may raise blood glucose, reducing the effect of antidiabetic drugs. Trifluoperazine has a lower metabolic liability than some other antipsychotics, so the effect is usually modest.
How serious is the interaction between Linagliptin-metformin and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when trifluoperazine is started or stopped and adjust antidiabetic therapy as needed.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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