Drug interactions
Linezolid + Lofepramine
Severity: Contraindicated
Linezolid and Lofepramine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine is a tricyclic that blocks noradrenaline and serotonin reuptake, and linezolid inhibits MAO. The combination raises the risk of serotonin syndrome and hypertensive reactions.
What this interaction means in plain words
Linezolid and Lofepramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive serotonergic and noradrenergic effects from MAO inhibition and reuptake blockade.
What to do
Avoid combination and use another antibiotic. If linezolid is essential, stop lofepramine and monitor for serotonin toxicity.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Linezolid with Lofepramine?
MediHelp rates the interaction as contraindicated. Linezolid and Lofepramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lofepramine is a tricyclic that blocks noradrenaline and serotonin reuptake, and linezolid inhibits MAO. The combination raises the risk of serotonin syndrome and hypertensive reactions.
How serious is the interaction between Linezolid and Lofepramine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination and use another antibiotic. If linezolid is essential, stop lofepramine and monitor for serotonin toxicity.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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