Drug interactions
Linezolid + Lsd
Severity: Major
Linezolid and Lsd: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
LSD is a potent serotonin receptor agonist, and MAO inhibition by linezolid may add to serotonergic stimulation, risking serotonin syndrome. Data are sparse and mostly theoretical.
What this interaction means in plain words
Linezolid and Lsd can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Serotonin receptor agonism by LSD combined with reduced monoamine metabolism through MAO inhibition by linezolid.
What to do
Avoid concurrent use. If a patient on linezolid has taken LSD, monitor mental status, temperature, neuromuscular signs and vital signs and treat serotonin syndrome supportively.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Linezolid with Lsd?
MediHelp rates the interaction as major. Linezolid and Lsd can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. LSD is a potent serotonin receptor agonist, and MAO inhibition by linezolid may add to serotonergic stimulation, risking serotonin syndrome. Data are sparse and mostly theoretical.
How serious is the interaction between Linezolid and Lsd?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use. If a patient on linezolid has taken LSD, monitor mental status, temperature, neuromuscular signs and vital signs and treat serotonin syndrome supportively.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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