Drug interactions
Linezolid + Metformin-sitagliptin
Severity: Moderate
Linezolid and Metformin-sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linezolid, a weak MAO inhibitor, has been associated with hypoglycemia in patients receiving antidiabetic drugs, mainly insulin and oral secretagogues. It has also been linked with lactic acidosis, which may be of concern alongside metformin.
What this interaction means in plain words
Linezolid and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linezolid belongs to Anti Bacterial; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Linezolid may enhance insulin action, and its mitochondrial toxicity can contribute to lactic acidosis, additive to the metformin risk.
What to do
Monitor blood glucose during linezolid therapy and watch for signs of lactic acidosis such as malaise, hyperventilation or abdominal pain; stop metformin if lactic acidosis is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Linezolid and Metformin-sitagliptin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Metformin-sitagliptin
Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Linezolid with Metformin-sitagliptin?
MediHelp rates the interaction as moderate. Linezolid and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linezolid, a weak MAO inhibitor, has been associated with hypoglycemia in patients receiving antidiabetic drugs, mainly insulin and oral secretagogues. It has also been linked with lactic acidosis, which may be of concern alongside metformin.
How serious is the interaction between Linezolid and Metformin-sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during linezolid therapy and watch for signs of lactic acidosis such as malaise, hyperventilation or abdominal pain; stop metformin if lactic acidosis is suspected.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
