Drug interactions
Linezolid + Metoclopramide intranasal
Severity: Major
Linezolid and Metoclopramide intranasal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linezolid is a weak MAO inhibitor, and metoclopramide has been associated with catecholamine release and with serotonergic or dopaminergic effects. The combination may raise blood pressure and raise the risk of serotonin syndrome or extrapyramidal effects.
What this interaction means in plain words
Linezolid and Metoclopramide intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Possible catecholamine release and additive serotonergic/dopaminergic effects in the presence of MAO inhibition; the mechanism is not fully established.
What to do
Prefer a different antiemetic or prokinetic during linezolid therapy. If used together, monitor blood pressure and watch for signs of serotonin syndrome.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Linezolid with Metoclopramide intranasal?
MediHelp rates the interaction as major. Linezolid and Metoclopramide intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Linezolid is a weak MAO inhibitor, and metoclopramide has been associated with catecholamine release and with serotonergic or dopaminergic effects. The combination may raise blood pressure and raise the risk of serotonin syndrome or extrapyramidal effects.
How serious is the interaction between Linezolid and Metoclopramide intranasal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a different antiemetic or prokinetic during linezolid therapy. If used together, monitor blood pressure and watch for signs of serotonin syndrome.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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