Drug interactions
Linezolid + Metrizamide
Severity: Moderate
Linezolid and Metrizamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metrizamide is an intrathecal contrast agent that lowers the seizure threshold. Drugs that also lower seizure threshold may increase seizure risk, and linezolid has been reported to cause seizures.
What this interaction means in plain words
Linezolid and Metrizamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive lowering of the seizure threshold; the mechanism is not well established.
What to do
Consider whether linezolid can be withheld around myelography and monitor for seizures afterwards. Keep seizure precautions in place after the procedure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Linezolid with Metrizamide?
MediHelp rates the interaction as moderate. Linezolid and Metrizamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metrizamide is an intrathecal contrast agent that lowers the seizure threshold. Drugs that also lower seizure threshold may increase seizure risk, and linezolid has been reported to cause seizures.
How serious is the interaction between Linezolid and Metrizamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider whether linezolid can be withheld around myelography and monitor for seizures afterwards. Keep seizure precautions in place after the procedure.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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