Drug interactions
Linezolid + Microbiota
Severity: Moderate
Linezolid and Microbiota: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral live microbiota products contain bacterial spores that must colonise the gut to work. Systemic antibiotics with activity against these organisms may reduce their survival and efficacy. Linezolid has broad Gram-positive activity, including against some spore-formers.
What this interaction means in plain words
Linezolid and Microbiota can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity of linezolid against the live bacterial components reduces colonisation and therapeutic effect.
What to do
Complete the linezolid course and allow an interval of at least 2 to 4 days before giving the microbiota product, in line with product labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Linezolid with Microbiota?
MediHelp rates the interaction as moderate. Linezolid and Microbiota can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral live microbiota products contain bacterial spores that must colonise the gut to work. Systemic antibiotics with activity against these organisms may reduce their survival and efficacy. Linezolid has broad Gram-positive activity, including against some spore-formers.
How serious is the interaction between Linezolid and Microbiota?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete the linezolid course and allow an interval of at least 2 to 4 days before giving the microbiota product, in line with product labeling.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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