Drug interactions
Linezolid + Papaveretum
Severity: Major
Linezolid and Papaveretum: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaveretum contains opium alkaloids including morphine. With MAO inhibitors, opioids can cause serotonin syndrome or marked opioid toxicity such as hypotension, respiratory depression and coma. Linezolid has weak MAO-inhibiting activity.
What this interaction means in plain words
Linezolid and Papaveretum can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
MAO inhibition by linezolid may potentiate serotonergic and CNS-depressant effects of opioids; the exact mechanism is uncertain.
What to do
Use an alternative analgesic where possible. If an opioid is needed, use small titrated doses and monitor blood pressure, respiratory status and signs of serotonin toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Linezolid with Papaveretum?
MediHelp rates the interaction as major. Linezolid and Papaveretum can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Papaveretum contains opium alkaloids including morphine. With MAO inhibitors, opioids can cause serotonin syndrome or marked opioid toxicity such as hypotension, respiratory depression and coma. Linezolid has weak MAO-inhibiting activity.
How serious is the interaction between Linezolid and Papaveretum?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative analgesic where possible. If an opioid is needed, use small titrated doses and monitor blood pressure, respiratory status and signs of serotonin toxicity.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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