Drug interactions
Linezolid + Same
Severity: Major
Linezolid and Same: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
S-adenosylmethionine (SAMe) has serotonergic activity, and linezolid is a reversible MAO inhibitor. Combination may cause serotonin syndrome.
What this interaction means in plain words
Linezolid and Same can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive serotonergic effect from MAO inhibition plus increased serotonin availability from SAMe.
What to do
Stop SAMe during linezolid therapy. Monitor for agitation, tremor, clonus and hyperthermia, and resume SAMe only after linezolid is finished.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Linezolid with Same?
MediHelp rates the interaction as major. Linezolid and Same can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. S-adenosylmethionine (SAMe) has serotonergic activity, and linezolid is a reversible MAO inhibitor. Combination may cause serotonin syndrome.
How serious is the interaction between Linezolid and Same?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop SAMe during linezolid therapy. Monitor for agitation, tremor, clonus and hyperthermia, and resume SAMe only after linezolid is finished.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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