Drug interactions
Linezolid + Selegiline transdermal
Severity: Contraindicated
Linezolid and Selegiline transdermal: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline is an MAO inhibitor, and at antidepressant transdermal doses it inhibits both MAO-A and MAO-B. Adding linezolid increases risk of serotonin syndrome and hypertensive reactions.
What this interaction means in plain words
Linezolid and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive MAO inhibition leading to excess serotonin and catecholamines.
What to do
Avoid the combination and use an alternative antibiotic. If linezolid is unavoidable, stop selegiline and monitor blood pressure and for serotonin toxicity.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Linezolid with Selegiline transdermal?
MediHelp rates the interaction as contraindicated. Linezolid and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Selegiline is an MAO inhibitor, and at antidepressant transdermal doses it inhibits both MAO-A and MAO-B. Adding linezolid increases risk of serotonin syndrome and hypertensive reactions.
How serious is the interaction between Linezolid and Selegiline transdermal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative antibiotic. If linezolid is unavoidable, stop selegiline and monitor blood pressure and for serotonin toxicity.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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