Drug interactions
Linezolid + Serdexmethylphenidate / dexmethylphenidate
Severity: Contraindicated
Linezolid and Serdexmethylphenidate / dexmethylphenidate: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylphenidate products are contraindicated with MAO inhibitors, and linezolid has MAO-inhibiting activity. Combining them can cause hypertensive crisis because of excess catecholamine accumulation.
What this interaction means in plain words
Linezolid and Serdexmethylphenidate / dexmethylphenidate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Linezolid inhibits MAO, which impairs catecholamine degradation, while methylphenidate increases synaptic dopamine and norepinephrine.
What to do
Do not give together or within 14 days of stopping an MAOI per labeling. If linezolid is required, hold the stimulant and monitor blood pressure.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Linezolid with Serdexmethylphenidate / dexmethylphenidate?
MediHelp rates the interaction as contraindicated. Linezolid and Serdexmethylphenidate / dexmethylphenidate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Methylphenidate products are contraindicated with MAO inhibitors, and linezolid has MAO-inhibiting activity. Combining them can cause hypertensive crisis because of excess catecholamine accumulation.
How serious is the interaction between Linezolid and Serdexmethylphenidate / dexmethylphenidate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give together or within 14 days of stopping an MAOI per labeling. If linezolid is required, hold the stimulant and monitor blood pressure.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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