Drug interactions
Linezolid + Sodium picosulfate / magnesium oxide / anhydrous citric acid
Severity: Moderate
Linezolid and Sodium picosulfate / magnesium oxide / anhydrous citric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium picosulfate is a prodrug activated by colonic bacteria. Antibiotics that reduce colonic flora may lessen its laxative effect and bowel cleansing. Linezolid has oral absorption and limited colonic exposure, so the effect is uncertain but plausible.
What this interaction means in plain words
Linezolid and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibiotic suppression of colonic bacteria needed to convert picosulfate to its active metabolite.
What to do
Where possible avoid starting linezolid before bowel preparation. Assess cleansing adequacy before colonoscopy and repeat the preparation if inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Linezolid with Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates the interaction as moderate. Linezolid and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium picosulfate is a prodrug activated by colonic bacteria. Antibiotics that reduce colonic flora may lessen its laxative effect and bowel cleansing. Linezolid has oral absorption and limited colonic exposure, so the effect is uncertain but plausible.
How serious is the interaction between Linezolid and Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible avoid starting linezolid before bowel preparation. Assess cleansing adequacy before colonoscopy and repeat the preparation if inadequate.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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