Drug interactions
Linezolid + Sufentanil sl
Severity: Major
Linezolid and Sufentanil sl: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sublingual sufentanil with an MAO inhibitor may cause serotonin syndrome or opioid toxicity such as respiratory depression and hypotension. Linezolid has weak MAO-inhibiting activity.
What this interaction means in plain words
Linezolid and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Possible serotonergic potentiation and enhanced opioid CNS depression with MAO inhibition.
What to do
Use a non-opioid or alternative analgesic where possible. If sufentanil is required, give carefully titrated low doses and monitor respiration, blood pressure and mental status.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Linezolid and Sufentanil sl, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Linezolid with Sufentanil sl?
MediHelp rates the interaction as major. Linezolid and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sublingual sufentanil with an MAO inhibitor may cause serotonin syndrome or opioid toxicity such as respiratory depression and hypotension. Linezolid has weak MAO-inhibiting activity.
How serious is the interaction between Linezolid and Sufentanil sl?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-opioid or alternative analgesic where possible. If sufentanil is required, give carefully titrated low doses and monitor respiration, blood pressure and mental status.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
