Drug interactions
Linezolid + Sumatriptan intranasal
Severity: Major
Linezolid and Sumatriptan intranasal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sumatriptan is metabolized by MAO-A, and linezolid inhibits MAO, so sumatriptan exposure may rise. Serotonin syndrome is also possible when serotonergic agents are combined with linezolid.
What this interaction means in plain words
Linezolid and Sumatriptan intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Reduced MAO-A metabolism of sumatriptan plus additive serotonergic activity.
What to do
Avoid sumatriptan while on linezolid and use a non-triptan migraine treatment. If both are used, monitor for serotonin toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Linezolid with Sumatriptan intranasal?
MediHelp rates the interaction as major. Linezolid and Sumatriptan intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sumatriptan is metabolized by MAO-A, and linezolid inhibits MAO, so sumatriptan exposure may rise. Serotonin syndrome is also possible when serotonergic agents are combined with linezolid.
How serious is the interaction between Linezolid and Sumatriptan intranasal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid sumatriptan while on linezolid and use a non-triptan migraine treatment. If both are used, monitor for serotonin toxicity.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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