Drug interactions
Linezolid + Trifluoperazine
Severity: Moderate
Linezolid and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linezolid is a weak MAO inhibitor and trifluoperazine is a potent dopamine antagonist with some serotonergic receptor activity. Combined use may rarely contribute to serotonin toxicity or neuroleptic malignant syndrome.
What this interaction means in plain words
Linezolid and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive monoaminergic effects from MAO inhibition and antipsychotic receptor antagonism.
What to do
Monitor for agitation, tremor, clonus, hyperthermia and rigidity during co-administration. Discontinue one or both agents if serotonin syndrome or NMS is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Linezolid with Trifluoperazine?
MediHelp rates the interaction as moderate. Linezolid and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linezolid is a weak MAO inhibitor and trifluoperazine is a potent dopamine antagonist with some serotonergic receptor activity. Combined use may rarely contribute to serotonin toxicity or neuroleptic malignant syndrome.
How serious is the interaction between Linezolid and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, clonus, hyperthermia and rigidity during co-administration. Discontinue one or both agents if serotonin syndrome or NMS is suspected.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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