Drug interactions
Linezolid + Typhoid vaccine live
Severity: Moderate
Linezolid and Typhoid vaccine live: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics active against Salmonella Typhi can reduce replication of the live oral typhoid vaccine strain. This may reduce immune response and protection.
What this interaction means in plain words
Linezolid and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity against the live attenuated vaccine strain decreases its viability.
What to do
Give oral live typhoid vaccine at least 3 days after the last antibiotic dose, or use the injectable inactivated vaccine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Linezolid with Typhoid vaccine live?
MediHelp rates the interaction as moderate. Linezolid and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antibiotics active against Salmonella Typhi can reduce replication of the live oral typhoid vaccine strain. This may reduce immune response and protection.
How serious is the interaction between Linezolid and Typhoid vaccine live?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oral live typhoid vaccine at least 3 days after the last antibiotic dose, or use the injectable inactivated vaccine.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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