Drug interactions
linezolid + tyramine-containing drugs (e.g., selegiline)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Hypertensive crisis risk.
Mechanism of action
MAOI effects.
Clinical management
Avoid dual MAO inhibition.
Drug reference
References
Frequently asked questions
Can I take linezolid with tyramine-containing drugs (e.g., selegiline)?
The interaction is rated: Major. Hypertensive crisis risk.
How serious is the interaction between linezolid and tyramine-containing drugs (e.g., selegiline)?
The interaction is rated: Major. Evidence level: Moderate.
How is the interaction between linezolid and tyramine-containing drugs (e.g., selegiline) managed?
Avoid dual MAO inhibition.
Why do linezolid and tyramine-containing drugs (e.g., selegiline) interact?
MAOI effects.
Full monographs, dosing and an interaction checker in the MediHelp app
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