Drug interactions
Linezolid + Xylometazoline
Severity: Moderate
Linezolid and Xylometazoline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linezolid is a weak reversible non-selective MAO inhibitor and may enhance the pressor effects of adrenergic agents. Xylometazoline is a topical nasal alpha-agonist with low systemic absorption, so the risk is mainly with excessive use, but labeling for MAOIs advises caution.
What this interaction means in plain words
Linezolid and Xylometazoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linezolid belongs to Anti Bacterial; Xylometazoline belongs to Respiratory.
Why it happens
MAO inhibition by linezolid may potentiate the pressor effects of absorbed alpha-adrenergic agonist.
What to do
Use xylometazoline only briefly and at the labeled dose in patients on linezolid. Monitor blood pressure and avoid use if hypertension is present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Xylometazoline
- Selegiline + Xylometazoline Contraindicated
- Ergotamine + Xylometazoline Major
- Isocarboxazid + Xylometazoline Major
- Phenelzine + Xylometazoline Major
- Tranylcypromine + Xylometazoline Major
- Amitriptyline + Xylometazoline Moderate
Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Linezolid with Xylometazoline?
MediHelp rates the interaction as moderate. Linezolid and Xylometazoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linezolid is a weak reversible non-selective MAO inhibitor and may enhance the pressor effects of adrenergic agents. Xylometazoline is a topical nasal alpha-agonist with low systemic absorption, so the risk is mainly with excessive use, but labeling for MAOIs advises caution.
How serious is the interaction between Linezolid and Xylometazoline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use xylometazoline only briefly and at the labeled dose in patients on linezolid. Monitor blood pressure and avoid use if hypertension is present.
What other medicines interact with Xylometazoline?
MediHelp also lists interactions of Xylometazoline with, for example, Selegiline, Ergotamine, Isocarboxazid. The full list is on the Xylometazoline page.
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