Drug interactions
Linezolid + Yohimbe
Severity: Moderate
Linezolid and Yohimbe: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine raises noradrenergic activity and has MAO-inhibiting properties. With linezolid, a weak MAO inhibitor, it may increase blood pressure and cause agitation or tachycardia.
What this interaction means in plain words
Linezolid and Yohimbe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive noradrenergic and MAO-inhibitory effects.
What to do
Advise patients to avoid yohimbe-containing supplements during linezolid therapy. Monitor blood pressure and heart rate if exposure occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Linezolid with Yohimbe?
MediHelp rates the interaction as moderate. Linezolid and Yohimbe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbine raises noradrenergic activity and has MAO-inhibiting properties. With linezolid, a weak MAO inhibitor, it may increase blood pressure and cause agitation or tachycardia.
How serious is the interaction between Linezolid and Yohimbe?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid yohimbe-containing supplements during linezolid therapy. Monitor blood pressure and heart rate if exposure occurs.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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