Drug interactions
Linezolid + Yohimbine
Severity: Major
Linezolid and Yohimbine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine is an alpha-2 antagonist that increases noradrenergic outflow and may raise blood pressure. Combined with MAO inhibition by linezolid, pressor effects may be amplified.
What this interaction means in plain words
Linezolid and Yohimbine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive noradrenergic effects: increased norepinephrine release from yohimbine and reduced degradation through MAO inhibition.
What to do
Avoid yohimbine during linezolid therapy. If used, monitor blood pressure and heart rate closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Linezolid with Yohimbine?
MediHelp rates the interaction as major. Linezolid and Yohimbine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Yohimbine is an alpha-2 antagonist that increases noradrenergic outflow and may raise blood pressure. Combined with MAO inhibition by linezolid, pressor effects may be amplified.
How serious is the interaction between Linezolid and Yohimbine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid yohimbine during linezolid therapy. If used, monitor blood pressure and heart rate closely.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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