Drug interactions
Linzagolix + Repaglinide
Severity: Major
Linzagolix and Repaglinide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linzagolix may raise repaglinide exposure, increasing the risk of hypoglycemia.
What this interaction means in plain words
Linzagolix and Repaglinide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Linzagolix belongs to Endocrine; Repaglinide belongs to Endocrine.
Why it happens
Linzagolix inhibits CYP2C8, a main repaglinide metabolic pathway.
What to do
Avoid combination or choose another antidiabetic agent; if combined, monitor blood glucose and consider a lower repaglinide dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Linzagolix and Repaglinide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Linzagolix
- Linzagolix + Paclitaxel Major
- Linzagolix + Sorafenib Major
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Linzagolix with Repaglinide?
MediHelp rates the interaction as major. Linzagolix and Repaglinide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Linzagolix may raise repaglinide exposure, increasing the risk of hypoglycemia.
How serious is the interaction between Linzagolix and Repaglinide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination or choose another antidiabetic agent; if combined, monitor blood glucose and consider a lower repaglinide dose.
What other medicines interact with Linzagolix?
MediHelp also lists interactions of Linzagolix with, for example, Paclitaxel, Sorafenib. The full list is on the Linzagolix page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
