Drug interactions
Linzagolix + Paclitaxel
Severity: Major
Linzagolix and Paclitaxel: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linzagolix inhibits CYP2C8 and may raise paclitaxel exposure. Paclitaxel has a narrow therapeutic index, so toxicity such as neutropenia and neuropathy may increase.
What this interaction means in plain words
Linzagolix and Paclitaxel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Linzagolix belongs to Endocrine; Paclitaxel belongs to Oncology.
Why it happens
Inhibition of CYP2C8-mediated paclitaxel metabolism by linzagolix.
What to do
Avoid combination; if needed, monitor blood counts and neuropathy closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Linzagolix and Paclitaxel, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Linzagolix
- Linzagolix + Repaglinide Major
- Linzagolix + Sorafenib Major
Other interactions of Paclitaxel
Frequently asked questions
Can I take Linzagolix with Paclitaxel?
MediHelp rates the interaction as major. Linzagolix and Paclitaxel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Linzagolix inhibits CYP2C8 and may raise paclitaxel exposure. Paclitaxel has a narrow therapeutic index, so toxicity such as neutropenia and neuropathy may increase.
How serious is the interaction between Linzagolix and Paclitaxel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination; if needed, monitor blood counts and neuropathy closely.
What other medicines interact with Linzagolix?
MediHelp also lists interactions of Linzagolix with, for example, Repaglinide, Sorafenib. The full list is on the Linzagolix page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
